From 08.04.2021, date of entry into force of EU regulation no. 2021/468, the various species of Aloe and related preparations containing hydroxyanthracene derivatives will no longer be sold in the food sector (with the exception of Aloe vera internal gel of the leaves declared with aloin <1 p.p.m.). Frangula, Rhubarb, Senna and their derivatives will remain salable under surveillance: the manufacturer of the food supplement or finished food must, however, check that the substances “Aloe-emodin, Emodin and Dantrone” in the finished product are below 1 p.p.m.
EU Regulation n. 2021/468
Annex III of Regulation (EC) no. 1925/2006 is amended as follows:
1) in part A (prohibited substances) the following items are inserted in alphabetical order:
“Aloe-emodin and all preparations in which this substance is present”;
“Emodin and all preparations in which this substance is present”;
“Preparations based on leaves of Aloe species containing hydroxyanthracene derivatives”;
“Dantrone and all preparations in which this substance is present”;
2) in part C (substances under surveillance) the following entries are inserted in alphabetical order:
‘Preparations based on the root or rhizome of Rheum palmatum L., Rheum officinale Baillon and their hybrids containing
hydroxyanthracene derivatives “;
“Preparations based on leaves or fruits of Cassia senna L. containing hydroxyanthracene derivatives”;
‘Preparations based on the bark of Rhamnus frangula L. or Rhamnus purshiana DC. containing hydroxyanthracene derivatives “.