Creatine is naturally present in our body and is synthesized starting from three amino acids (glycine, arginine, methionine). Mainly known for its effectiveness in increasing muscle tone and mass, it also contributes to proper functioning of the nervous and cardiovascular systems. Creatine is widely used in sports as an ergogenic aid, although recent evidence has also characterized a very interesting antioxidant, cardioprotective and neuroprotective activity. Creatine has also been used successfully in the clinical setting, in pathologies such as muscular dystrophy, amyotrophic lateral sclerosis, sarcopenia, cachexia and in heart failure.
Creatine is combined with alpha-ketoglutaric acid. The latter is an intermediate of the Krebs cycle, which is very important for the production of energy. So the sum of creatine to alpha-ketoglutaric acid gives an energy production (ATP) clearly superior to simple creatine monohydrate. It is very similar to sick creatine, with the advantage of better stabilizing the creatine molecule at gastric pH, thus reducing the percentage degraded by the stomach.