Creatine is naturally present in our body and is synthesized from three amino acids (glycine, arginine, methionine). Mainly known for its effectiveness in increasing muscle tone and mass, it also contributes to proper functioning of the nervous and cardiovascular systems. Creatine is widely used in sports as an ergogenic aid, although recent evidence has also characterized a very interesting antioxidant, cardioprotective and neuroprotective activity. Creatine has also been used successfully in the clinical setting, in the course of diseases such as muscular dystrophy, amyotrophic lateral sclerosis, sarcopenia, cachexia and in heart failure.
Creatine monohydrate was one of the first forms to be introduced on the market; it is the most used, therefore the most studied.